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VIRIP and its derivatives remained effective against drug-resistant HIV strains, making them "highly promising for further clinical development," according to the researchers.
VIRIP is a 20-residue peptide, corresponding to a fragment of the highly abundant serine protease inhibitor α1-antitrypsin, which strongly inhibits HIV-1 infection and transmission in human ...
Kirchhoff calls the newly discovered factor VIRIP, and it was shown in test-tube studies to inhibit 60 strains of HIV. His study describing the peptide was released Thursday by the journal Cell.
The team found that fragments of a blood molecule they call Virus-Inhibitory Peptide (VIRIP) inhibit HIV-1 and that making a few amino acid changes increased VIRIP's ability to block the virus.
German researchers have found a peptide in human blood that blocks HIV and have identified a synthetic variant that is 100 times more potent, they reported Friday in the journal Cell.
研究人员将它命名为病毒抑制缩氨酸VIRIP。 VIRIP可以干扰艾滋病病毒HIV-1型病毒的表面蛋白GP41,使其不能发挥作用,从而阻止HIV-1病毒附着到人体细胞 ...
Kirchhoff calls the newly discovered factor VIRIP, and it was shown in test-tube studies to inhibit 60 strains of HIV. His study describing the peptide was released Thursday by the journal Cell.
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