Vegfc−/− mice show aplasia of the lymphatic vasculature and tissue edema, leading to the death of homozygous mice before E18.5.

本研究聚焦胃癌 (GC)侵袭转移机制，来自国内的研究团队通过674例患者队列分析，揭示胸苷磷酸化酶 (TYMP)与Sine Oculis同源盒蛋白1 (Six1)共表达可显著促进血管内皮生长因子C (VEGFc)分泌，增强癌细胞迁移能力，并与免疫抑制性微环境显著相关。该发现为胃癌预后评估提供了新型生物标志物组合。

miR-128-3p在神经元分化、心血管疾病和代谢调控中已有明确功能，近年研究发现其通过调控c-Met、VEGFC等靶点参与多种癌症进程。 与lncRNA（如PVT1）和circRNA（如circ-ABCB10）形成的ceRNA网络进一步扩展了其调控维度。 Functional roles in human cancers ...

VEGFC preferably binds to the VEGFR3, which is predominantly expressed on lymphatic vessels. Overexpression of VEGFC may therefore result in the establishment of intratumoral lymphatic vessels, which ...

Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation. Journal of Clinical Investigation, 2022; 132 (9) DOI: 10.1172/JCI140685 ...

"It is a Dr. Jekyll and Mr. Hyde scenario, with 'good' macrophages that induce VEGFC and the 'bad' ones that don't. We need to prevent the 'bad' macrophages from causing further damage," said co ...

The challenge now is to find a way either to administer VEGFC or to coax these macrophages to induce more VEGFC, to speed the heart repair process. People who suffer a heart attack are at high ...

New research reveals how the heart repairs after a heart attack Peer-Reviewed Publication Ann & Robert H. Lurie Children's Hospital of Chicago ...