未来研究若能结合功能实验验证VEGFC等候选基因的生理效应，将进一步提升该结论的可靠性。 这项发表于《Molecular Phylogenetics and Evolution》的工作，不仅为生物杂交的进化意义提供了关键案例，也为探索生命如何征服地球极端环境打开了新视角。

本研究聚焦胃癌 (GC)侵袭转移机制，来自国内的研究团队通过674例患者队列分析，揭示胸苷磷酸化酶 (TYMP)与Sine Oculis同源盒蛋白1 (Six1)共表达可显著促进血管内皮生长因子C (VEGFc)分泌，增强癌细胞迁移能力，并与免疫抑制性微环境显著相关。该发现为胃癌预后评估提供了新型生物标志物组合。

VEGF是一组重要调节因子，能够刺激新血管的生长（血管生成）并增加现有血管的渗透性，VEGF包括VEGFA（最为常见）、VEGFB、VEGFC、VEGFD、VEGFE以及PLGF等 ...

VEGFC preferably binds to the VEGFR3, which is predominantly expressed on lymphatic vessels. Overexpression of VEGFC may therefore result in the establishment of intratumoral lymphatic vessels, which ...

Huang and colleagues also found that the major VEGFR3 ligand, VEGFC, was downregulated during the early stages of cystogenesis in mice with autosomal dominant PKD.

Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation. Journal of Clinical Investigation, 2022; 132 (9) DOI: 10.1172/JCI140685 ...

"It is a Dr. Jekyll and Mr. Hyde scenario, with 'good' macrophages that induce VEGFC and the 'bad' ones that don't. We need to prevent the 'bad' macrophages from causing further damage," said co ...

The challenge now is to find a way either to administer VEGFC or to coax these macrophages to induce more VEGFC, to speed the heart repair process. People who suffer a heart attack are at high ...