金融界2024年9月30日消息，国家知识产权局信息显示，浙江格物致知生物科技有限公司申请一项名为“一种GFAP、NFL和UCH-L1联合检测试剂盒及其用于脑 ...

糖尿病多发性神经病变（DPN）缺乏敏感客观的检测和监测工具。研究人员开展了 DPN 患者血清中胶质纤维酸性蛋白（GFAP）和泛素羧基末端水解酶 - L1（UCH-L1）水平的研究。结果显示 DPN 患者血清 GFAP 水平降低，或与小神经纤维损伤有关，为 DPN 生物标志物研究提供新方向。

来自意大利卡塔尼亚大学附属医院的研究人员针对轻度创伤性脑损伤 (mTBI)临床异质性导致的急诊科管理难题，开展了一项观察性研究。该团队评估了胶质纤维酸性蛋白 (GFAP)和泛素羧基末端水解酶L1 (UCH-L1)对CT检查必要性的预测效能，结果显示经神经放射专家盲法复核后，生物标志物的阴性预测值 (NPV ...

Banyan BTI包括2个试剂盒（Banyan UCH-L1®试剂盒和Banyan GFAP®试剂盒），可测定脑损伤后血液中很快出现的2种特异性蛋白质生物标记物。

The study analyzed blood samples of 548 TBI patients up to 180 hours post-injury for two biomarkers. Higher concentrations of UCH-L1 were found in men compared with women within 24 hours of testing.

More information: Jussi P. Posti et al, Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury, Journal of ...

Relying on elevated levels of the proteins GFAP and UCH-L1 to identify patients with mTBI could lead to false-positive diagnoses and unnecessary brain imaging, as reported in an article in Journal ...

Measuring GFAP and UCH-L1 in blood on the day of injury may give a more accurate assessment of a patient's prognosis following traumatic brain injury, new research suggests.

Objective To characterize levels of plasma GFAP, NF-L, UCH-L1, T-tau, and p-tau181 in healthy youth athletes considering the influence of previous concussion, age, sex, menstrual cycle stage, and sex ...

According to data in the paper, UCH-L1M does not affect proteasome function, suggesting that it instead regulates the lysosomal pathway of synuclein degradation first described by Anna-Maria Cuervo ...