金融界2024年9月30日消息，国家知识产权局信息显示，浙江格物致知生物科技有限公司申请一项名为“一种GFAP、NFL和UCH-L1联合检测试剂盒及其用于脑 ...

来自意大利卡塔尼亚大学附属医院的研究人员针对轻度创伤性脑损伤 (mTBI)临床异质性导致的急诊科管理难题，开展了一项观察性研究。该团队评估了胶质纤维酸性蛋白 (GFAP)和泛素羧基末端水解酶L1 (UCH-L1)对CT检查必要性的预测效能，结果显示经神经放射专家盲法复核后，生物标志物的阴性预测值 (NPV ...

为解决脓毒症相关性脑病（SAE）诊断和预后评估难题，研究人员开展了血清神经源性生物标志物（NSE、UCH-L1、Tau、S100β、GFAP）在 SAE 中诊断和预后价值的研究。结果显示，SAE 患者及非存活脓毒症患者的这些标志物水平更高。该研究有望为 SAE 诊疗提供参考。

Banyan BTI包括2个试剂盒（Banyan UCH-L1®试剂盒和Banyan GFAP®试剂盒），可测定脑损伤后血液中很快出现的2种特异性蛋白质生物标记物。

Levels of the biomarkers GFAP, UCH-L1, and MAP-2 spiked within 30 minutes of traumatic brain injury, with GFAP diagnosing intracranial lesions and predicting critical outcomes most accurately.

Relying on elevated levels of the proteins GFAP and UCH-L1 to identify patients with mTBI could lead to false-positive diagnoses and unnecessary brain imaging, as reported in an article in Journal ...

Uch-L1 acts as the proteasome's "gatekeeper," he added. Before proteins can be eliminated by the proteasome, Uch-L1 must remove their ubiquitin tag.

The study analyzed blood samples of 548 TBI patients up to 180 hours post-injury for two biomarkers. Higher concentrations of UCH-L1 were found in men compared with women within 24 hours of testing.

More information: Jussi P. Posti et al, Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury, Journal of ...

The biomarker GFAP, short for glial fibrillary acidic protein, peaked at 20 hours but "was working consistently over the seven days," she said. UCH-L1 peaked more quickly, within eight hours.