Transdifferentiation: Going straight to the source of vascular disease by University of Tsukuba Credit: AI-generated image (disclaimer) ...

says senior author Professor Hiromi Yanagisawa. "We wanted to know whether the transdifferentiation of endothelial cells into smooth muscle cells is an important contributor to neointimal formation." ...

Moreover, alteration of drug resistance related SLC7A5, SLC3A2, and SLC25A24 genes was observed. Additionally, an enrichment analyses identified, among others, neuroendocrine transdifferentiation ...

Conclusions: These results identify common and divergent dysregulated pathways in NE and LUSC transdifferentiation, and nominate AKT as a therapeutic target to prevent the acquisition of resistance to ...

In conclusion, this work highlights mechanisms modulating cellular plasticity that may constitute the very first step of transdifferentiation and metaplasia development in the oesophagus.