Transdifferentiation often involves finding triggers that erase a cell’s identity and give it another. Sometimes these are small chemicals that activate a developmental pathway. More often they’re ...

Transdifferentiation refers to a physiologic process of alteration of one distinct phenotypic cell into another during development and differentiation. The concept that the small lymphocyte is capable ...

Transdifferentiation: Going straight to the source of vascular disease by University of Tsukuba Credit: AI-generated image (disclaimer) ...

says senior author Professor Hiromi Yanagisawa. "We wanted to know whether the transdifferentiation of endothelial cells into smooth muscle cells is an important contributor to neointimal formation." ...

Moreover, alteration of drug resistance related SLC7A5, SLC3A2, and SLC25A24 genes was observed. Additionally, an enrichment analyses identified, among others, neuroendocrine transdifferentiation ...

Conclusions: These results identify common and divergent dysregulated pathways in NE and LUSC transdifferentiation, and nominate AKT as a therapeutic target to prevent the acquisition of resistance to ...

Masatoshi Yamaguchi, Nadia Goué, Hisako Igarashi, Misato Ohtani, Yoshimi Nakano, Jennifer C. Mortimer, Nobuyuki Nishikubo, Minoru Kubo, Yoshihiro Katayama, Koichi Kakegawa, Paul Dupree, Taku Demura, ...

The jellyfish cells are able to undergo a process called transdifferentiation that allows T. dohrnii to revert back to a younger life cycle – much like a 40-year-old human who could go back to ...

In conclusion, this work highlights mechanisms modulating cellular plasticity that may constitute the very first step of transdifferentiation and metaplasia development in the oesophagus.

Transdifferentiation is the process by which one type of cell can convert into another type of cell. In jellyfish, this process allows them to revert to their juvenile polyp stage after they have ...