When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS ...

CHICAGO – Decreased activity within the Transforming Growth Factor Beta (TGF-beta) pathway is associated with increased breast cancer risk, according to a study published by researchers at ...

CAFs in TME: key Immunosuppressors. Secreting CXCLs, ILs, TGF-β, CCL12, PGE2, CAFs promote pro-cancer macrophage conversion, inactivate NK cells, and hinder CD8+T cell aggregation. Immune cells like ...

A central driver of this process is Transforming Growth Factor-Beta (TGF-β), a cytokine ... several SMAD-independent pathways, including PI3K/Akt, MAPK (ERK, JNK, p38), and TAK1, which synergize with ...

DUBLIN – The contest to develop new therapeutics targeting transforming growth factor beta 1 (TGF-beta1) signaling in cancer intensified this week, as both Abbvie Inc. and Scholar Rock Holding Corp.

Please provide your email address to receive an email when new articles are posted on . Transforming growth factor beta mutation biomarkers may help identify patients at high risk for cancer of the ...