维持蛋白质稳态（proteostasis）依赖细胞内多种机制协同作用。然而，随着衰老、基因突变或环境应激的累积，错误折叠的蛋白质可能逃避免疫监控并发生聚集，从而诱发神经退行性疾病等蛋白质聚集病。长期以来，蛋白稳态维持被视为细胞自主的过程，但近年 ...

Investigating the association of WNT pathway dysregulation and young-onset colorectal cancer. This is an ASCO Meeting Abstract from the 2024 ASCO Gastrointestinal Cancers Symposium. This abstract does ...

本研究揭示了牛乳源细胞外囊泡（Mi-EVs）通过抑制TGF-β1/Smad3信号通路，显著减轻系统性硬化症（SSc）小鼠模型皮肤纤维化的 ...

When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS ...

这篇综述揭示了TGF-β扩增的Vγ9Vδ2 γδ T细胞通过诱导中央记忆表型（CD45RO+CCR7+）和降低终末分化标志物（CD57/KLRG1），显著提升 ...

The central image depicts currently used strategies for clinical targeting of TGF-β. Below are methods applicable from preclinical screening to clinical practice, including using humanized mouse ...

Transforming growth factor beta (TGF-β) is a ubiquitous and essential regulator of cellular and physiologic processes including proliferation, differentiation, migration, cell survival, angiogenesis, ...

Transforming growth factor beta 1 (TGFB1), also known as TGF-β1, CED, DPD1, and TGFB, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein ...

A single chemical is key to controlling when hair follicle cells divide, and when they die. This discovery could not only treat baldness, but ultimately speed wound healing because follicles are a ...