TCR触发后，通过CD3亚基的免疫受体酪氨酸激活基序（ITAM）启动信号级联，驱动T细胞增殖和效应功能。 这一过程涉及膜蛋白、胞内信号分子和转录因子的协同作用，形成经典的"三信号模型"：抗原识别（信号1）、共刺激（信号2）和细胞因子（信号3）。

为解决异质性抗原表达导致的肿瘤复发和TCR缺失型通用CAR-T细胞无法协同CD3靶向T细胞衔接器 (TCEs)的问题，研究人员通过诱导多能干细胞 (iPSC)技术构建了表达CD3ε融合受体 (CD3FR)的CAR iT细胞。该研究证实CD3FR+ CAR iT细胞能有效介导TCEs的多抗原靶向作用，并在体内外展现协同抗肿瘤活性，为克服抗原逃逸 ...

T细胞衔接器（T Cell Engager, TCE）是一种双特异性或多特异性抗体，可以同时靶向肿瘤相关细胞表面抗原（Tumor-Associated Antigen，TAA）和T细胞表面受体（T-Cell ...

基于菲鹏制药CD3/TCR纳米抗体,公司开发了同时靶向CD19和BCMA双靶标TCE治疗系统性红斑狼疮 (SLE)、含第二信号的三抗TCE治疗实体瘤、偏向性CD8⁺T TCE治疗 ...

Conclusions: Endogenous CD3 chains are rate-limiting for TCR expression and antigen-specific function in gene modified T cells.The data demonstrate that provision of additional CD3 molecules is an ...

The effects of anti-CD3 antibodies on the immune system are diverse and incompletely understood at this moment; TCR blockade and internalization, shifting the Th1/Th2 balance, induction of T-cell ...

Anti-CD3/CD28 antibody-coupled magnetic beads can effectively expand T cells and have a higher expansion ability than that of other competitors The purified human T cells were stimulated using ...