McNally and his team cracked open their pyridine compounds by modifying a technique published in 1904 called the Zincke reaction (Science 2022, DOI: 10.1126/science.add8980). The researchers used ...

Scope We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as ...

Chemists, for the first time, have tested a computer program’s ability to plan complete syntheses without human help, following the proposed routes in the lab (Chem 2018, DOI: 10.1016/j.chempr ...

Syntheses of several 1-vinylcycloalkenes and 1-substituted-1,3-butadienes achieved yields up to 99% (1). The approach has also been applied to other biologically relevant classes of compounds, ...