This leads to the GRB1 protein acting like a bridge, leading to large, flexible domains rich in GRB2 and SOS1. This is the first time a mechanism has been proposed for LLPS of GRB2 and SOS1.

Signal transduction by GRB2 and SOS1. When some substances bind to a membrane receptor, a reaction occurs between the receptor and GRB2, which then goes on to bind and activate SOS1. SOS1 can then ...

Son of sevenless 1 (SOS1) is a guanine exchange factor (GEF) primarily responsible for linking cell-surface receptors to RAS protein activation converting the inactive form of GDP-loaded RAS proteins ...

SOS1::KRAS inhibitors exhibit activity on a broad spectrum of KRAS alleles, including all major G12D/V/C and G13D oncoproteins, as recently published by Hofmann MH, et al. in Cancer Discovery, a ...

SOS1::KRAS inhibitors exhibit activity on a broad spectrum of KRAS alleles, including all major G12D/V/C and G13D oncoproteins, as published by Hofmann MH, et al. in Cancer Discovery, a journal of ...

Suppressor of sessile spikelets1 (Sos1) is a dominant mutant of maize that blocks branching of the spikelet-pair primordium to form the sessile spikelet during ear development. As a result, Sos1 ...

CHICAGO, April 28, 2025--Schrödinger, Inc. (Nasdaq: SDGR) presented preclinical data on SGR-3515, its investigational Wee1/Myt1 co-inhibitor today at the American Association for Cancer Research ...

SOS1::KRAS inhibitors exhibit activity on a broad spectrum of KRAS alleles, including all major G12D/V/C and G13D oncoproteins, as recently published by Hofmann MH, et al. in Cancer Discovery, a ...