研究结论与讨论 本研究揭示了 S100B 在 ARSACS 胶质细胞模型中对 sacsin 缺失的功能补偿作用。 S100B 通过聚集于中间丝和线粒体损伤位点，发挥分子伴侣功能，抑制神经丝蛋白聚集并维持线粒体网络形态，但其对线粒体能量代谢功能的保护作用有限。

本研究针对贝伐珠单抗 (BEV)治疗卵巢癌时出现的耐药性问题，通过构建BEV敏感和耐药的小鼠模型，结合RNA测序和机器学习方法，鉴定出S100B是调控卵巢癌BEV敏感性的关键分子。研究发现S100B通过clathrin介导的内吞作用进入内皮细胞，下调FOXO1表达，促进β-catenin核转位，从而增强血管生成。S100B抑制剂喷 ...

Elevated S100B serum concentrations (a) and an increased C-peptide/glucose ratio (b), indicating insulin resistance, were schizophrenia related.

The cytokine S100B has a reputation as a bad guy in Alzheimer’s disease, revving up inflammation and amyloidosis. Now, new research complicates that view, uncovering a potential beneficial role for ...

S100B testing results showed that the higher the S100B level is, the higher the risk of relapse and death, regardless of the cutoff value. Univariate analysis showed that baseline S100B ≥ 0.15 μg/L is ...

S100B is released into the blood stream by astrocytes in the brain when brain injury occurs. The authors investigated whether a specific threshold level of S100B would indicate the absence of ...

The first report concerning serum S100B as a possible biomarker in MHI was published in 1995. [15] Since then, numerous reports and a meta-analysis, documenting the potential of S100B to safely ...

S100B is released into the blood stream by astrocytes in the brain when brain injury occurs. The authors investigated whether a specific threshold level of S100B would indicate the absence of ...