Robo2 appears to be expressed in discrete, dispersed regions in the surface ectoderm (Fig. 2g,h), characteristic of cells about to detach. All ingressed GFP-positive cells are also Robo2 -positive.

Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nature Communications, 2014; 5: 4831 DOI: 10.1038/ncomms5831 ...

Researchers have published a new study that suggests a signaling pathway called ROBO2 is a therapeutic target for kidney diseases, specifically kidney podocyte injury and glomerular diseases.

This is the first time the ROBO2 pathway has been linked to glomerular diseases such as membranous nephropathy (affecting the filters) and focal segmental glomerulosclerosis (scarring in the kidney).

The ROBO2 protein also closely interacts with other ROBO proteins that have previously been linked to problems with reading and the storage of speech sounds. Dr Beate St Pourcain, ...

"As ROBO2 podocyte expression is well conserved among different mammalian species, our research suggests that ROBO2 is a novel drug target for glomerular diseases such as membranous nephropathy ...

The ROBO2 gene is a robo receptor that binds Slit guidance ligands with functions linked to cell adhesion, growth and survival. Slit-Robo signaling is involved with many aspects of heart development.

Further information Paper ‘Common Variation Near ROBO2 is Associated with Expressive Vocabulary in Infancy’ by St Pourcain et al in Nature Communications. About the MRC The Medical Research Council ...

ROBO2 appears to be specific to the early development stage of one-word communication. More work is needed to uncover how its functions are affected by other DNA variations nearby, and what the ...