Duloxetine is a dual inhibitor of norepinephrine (NE) and serotonin (5-HT) uptake. Initial trials conducted in depressed patients using regimens of 20 mg/day or less did not convincingly demonstrate ...

Objective To compare the efficacy and tolerability of tricyclic antidepressants with selective serotonin reuptake inhibitors in depression in primary care. Design Systematic review and meta-analysis ...

Background: Selective serotonin reuptake inhibitors are increasingly used in the long-term treatment of depression. Much of the supporting evidence about the effects of these drugs comes from ...

Children whose mothers took antidepressants during pregnancy are not more likely to develop long-term anxiety or depression ...

Ian Goodyer, Bernadka Dubicka, Paul Wilkinson, Raphael Kelvin, Chris Roberts, Sarah Byford, Siobhan Breen, Claire Ford, Barbara Barrett, Alison Leech, Justine ...

Some antidepressants, such as fluoxetine (Prozac), work by preventing neurons from vacuuming up the neurotransmitter serotonin from the gaps between brain cells—a process called reuptake. By doing so, ...

Findings from a new study show that selective serotonin reuptake inhibitor use during pregnancy and lactation may alter ...

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About 5% of adults worldwide live with depression, a mental health condition characterized by feelings of sadness, hopelessness, and an inability to experience joy. One common treatment for depression ...

Monoamine oxidase inhibitors were linked to the highest risk for cardiovascular Standardized MedDRA Queries. Dopamine reuptake inhibition and binding inhibition are linked to antidepressant-related ...