The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.

PURPOSEHomologous recombination deficiency (HRD) is highly prevalent in triple-negative breast cancer (TNBC) and associated with response to PARP inhibition (PARPi). Here, we studied the prevalence of ...

Homologous recombination deficiency (HRD) is a well-described phenotype of some prostate cancers; however, current biomarkers for HRD are imperfect and rely on detection of single gene alterations in ...

A team of Chinese researchers has developed two new genome editing technologies, known collectively as Programmable ...

Homologous recombination (HR) is an important process that plays multiple crucial roles during meiosis, a type of cell cycle dedicated to sexual reproduction. During HR, homologous DNA molecules ...

Perovskite devices break new records Li and colleagues identified the built-in electric field in the homojunction using a cross-sectional Kelvin probe microscopy technique. They found that this field ...

A Fluorescence Sperm Assay for Germline Recombination Analysis We expect the analysis of the role of Spo11 in meiosis to add tremendously to our ongoing efforts aimed at understanding recombination ...

Genetic recombination is the transmission-genetic process by which the combinations of alleles observed at different loci in two parental individuals become shuffled in offspring individuals. In ...

Polyploidization and recombination are two important processes driving evolution through the building and reshaping of genomes. Allopolyploids arise from hybridization and chromosome doubling among ...

Recombination between homologous, but non-allelic, stretches of DNA such as gene families, segmental duplications and repeat elements is an important source of mutation. In humans, recent studies have ...