A bitter taste receptor, TAS2R14, has been shown to respond to both extracellular and intracellular signals. Indeed, it can respond to both signals simultaneously. This finding is especially ...

Our biological processes rely on a system of communications — cellular signals — that set off chain reactions in and between target cells to produce a response. The first step in these often complex ...

Relationship of STAT3-mediated treatment resistance on activated MAPK signaling in pancreatic cancer. Background: Metastatic tumors may be fundamentally different than the primary tumor. This ...

Allosteric modulation provides exciting opportunities for drug discovery of enzymes, ion channels, and G protein-coupled receptors. As cation channels gated by extracellular ATP, P2X receptors have ...

University of Oregon researchers have identified protein interactions that regulate the response of cells to steroid hormones. The discovery, they say, could lead to new ways to boost the ...

The partnership will harness AI modelling techniques to determine the ideal receptor binding profiles for new compounds.

Informative Censoring of Progression-Free Survival Data in the TROPiCS-02 Trial: An Unrecognized Bias The following represents disclosure information provided by the author of this manuscript. All ...

Universitätsmedizin Berlin have discovered a key mechanism for appetite and weight control. It helps the brain to regulate ...

At 15 years old, Sammy considered himself an expert on cannabis. When I asked what he knew about how marijuana interacts with the brain, he confidently explained, “THC activates cannabinoid receptors ...