CAMBRIDGE, Mass., May 14, 2025 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader in cellular metabolism and pyruvate kinase (PK) activation pioneering therapies for rare ...

This article reports that the DNA/RNA-binding protein Y-box binding protein 1 (YBX1) is localized to the mitochondrial inter-membrane space by its C-terminal domain (CTD) in cancer cells.

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...

Cheap, eco-friendly catalyst opens new possibilities for organic molecules built from pyruvate Date: March 24, 2022 Source: Okinawa Institute of Science and Technology (OIST) Graduate University ...

Pyruvate kinase deficiency, a rare hereditary disease that is characterized by chronic hemolytic anemia, results in numerous serious complications and a reduced health-related quality of life. 1-3 ...

Indications: Pyruvate dehydrogenase complex deficiency, typically associated with post-prandial lactic acidemia with a normal lactate/pyruvate ratio, can be assayed in freshly isolated blood ...

Pyruvate kinase deficiency has been identified in over 500 families. However, research shows that the condition could be highly underdiagnosed, as there is no way to identify mild cases.

Pyruvate supplementation has been shown to ameliorate hyperglycemia, retinopathy and nephropathy in experimental diabetic animals; however, neither the significance of pyruvate as an antioxidant ...

But when oxygen is limited, the body temporarily converts pyruvate into a substance called lactate, which allows glucose breakdown—and thus energy production—to continue.

For lactate and pyruvate analysis, arterial blood collected in a syringe was transferred within twenty seconds to weighed flasks of chilled 3.5 per cent perchloric acid.