研究人员针对自身免疫疾病与淋巴恶性肿瘤的相互作用机制展开研究，发现两类疾病存在共同的遗传损伤（genetic lesions）和病理细胞状态（pathogenic cell states）。研究表明，负向选择（negative selection）机制不仅清除自身反应性淋巴细胞（autoreactive ...

Pathogenic germline variants are observed in 10%-12% of children with cancer. 11 - 13 One study found that approximately 4% of patients with advanced adult cancers harbored pathogenic germline ...

BACKGROUND: Inflammatory, myocarditis-like episodes precede and are associated with higher risk of sustained ventricular arrhythmias and heart failure in patients with pathogenic or likely pathogenic ...

In total, 3,706 patients with GC underwent genetic testing, of which 494 (13.3%) patients carried PGVs, 1,200 (32.4%) had variants of uncertain significance, and 1,890 (51%) had negative testing. PGVs ...

New way to force pathogenic proteins into degradation Researchers develop novel cancer protein killer and discover a new ligase for PROTACs Date: December 11, 2023 Source: Max Planck Institute of ...

Rosnilimab, a selective depleter of pathogenic T cells, is a potential game changer for the treatment of moderate-to-severe ...

Mycobacteria are a group of pathogenic bacteria that cause diseases like leprosy and tuberculosis in humans. Now, a new study finds that mycobacteria are associated with red blood cells at lung ...