Researchers have discovered that a particular molecular signaling pathway plays an important role in producing osteoarthritis (OA) pain. Using a mouse model of painful osteoarthritis, they show that ...

Pain-sensing nerves and immune cells work together to wreak havoc in endometriosis, a painful condition that affects an estimated 190 million women and girls of reproductive age. But a study in mice ...

Scientists have re-created a pain pathway in the brain by growing four key clusters of human nerve cells in a dish. This laboratory model could be used to help explain certain pain syndromes, and ...

Activating a circuit between the amygdala and brainstem relieves pain and reduces defensive behaviors in rats, according to research recently published in JNeurosci. People with pain often experience ...

As detailed in a Stanford-led study published in Nature, researchers successfully created a replica of a neuronal pathway responsible for pain transmission in a lab dish called an “assembloid.” The ...