Protein Tyrosine Phosphatase 1B (PTP1B) is a critical regulator of multiple intracellular signalling pathways, notably those governing insulin and leptin action. Extensive research has elucidated ...

Nerio Therapeutics Inc. has synthesized proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase-binding moiety coupled to a tyrosine-protein phosphatase non-receptor type 1 ...