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原型泡沫病毒(PFV)是 FVs 中特殊的存在,它是目前已知唯一能跨物种传播给人类的泡沫病毒,虽然在人体内还未表现出致病性,但潜在风险不容小觑。PFV 的基因组编码多种蛋白,其中 Tas 蛋白作为关键的转录调节因子,对病毒复制起着至关重要的作用。Tas 蛋白能直接与 PFV 的长末端重复序列(LTR ...
The majority of PFV intasome search events were non-productive. These observations identify new dynamic IN functions and suggest that target site-selection limits retroviral integration.
PFV / Maison Bernard Julien de Beaumarchais de Rothschild, of Baron Philippe de Rothschild, noted that ‘If you give a bad violinist a Stradivarius, he will make bad music.’ ...