这篇综述系统解析了增殖细胞核抗原（PCNA）在纤毛虫中的进化与功能双重性，通过比较基因组学、AlphaFold3结构预测（含嗜热四膜虫、游仆虫等模型）揭示其保守的DNA复制支架功能（如三聚化界面、PIP-box基序）与谱系特异性创新（如复制带组装、表观调控），为理解真核生物基因组可塑性提供新视角。

The PCNA LI was 280.9 ± 226/1000 cells in end-of-treatment responders and 212.5 ± 216/1000 cells in end-of-treatment non-responders with no significant difference between both groups.

Alla Polotskaia, Gu Xiao, Katherine Reynoso, Che Martin, Wei-Gang Qiu, Ronald C. Hendrickson, Jill Bargonetti, Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of ...

BUFFALO, NY – June 4, 2025 – A new research paper was published in Volume 16 of Oncotarget on May 20, 2025, titled “Targeting PCNA/AR interaction inhibits AR-mediated signaling in castration ...

Researchers at City of Hope today published a new study explaining how they took a protein once thought to be too challenging for targeted therapy, proliferating cell nuclear antigen (PCNA), and ...

PCNA exerts a tripartite function by operating as (1) a sliding clamp during DNA synthesis, (2) a polymerase switch factor and (3) a recruitment factor. Most of its functions are mediated by its ...

Yusuf Uzun; Hakan Bozkaya; Esra Erden; Kubilay Cinar; Ramazan Idilman; Cihan Yurdaydin; and Ozden Uzunalimoglu Disclosures J Gastroenterol Hepatol. 2006;21 (6):977-981.