在一项新的研究中，来自美国宾夕法尼亚大学佩雷尔曼医学院和斯坦福大学医学院的研究人员设计出一对人正交IL-2（orthogonal IL-2, ortho-hIL-2）和人 ...

Combining spectral proper orthogonal decomposition and phase-averaging techniques provides methods for delineating ...

In this talk, I will discuss challenges and opportunities in the development of orthogonal metabolic platforms to efficiently biomanufacture small organic molecules for chemical and pharmaceutical ...

Combining orthogonal loss-of-function (LOF) methods in parallel (orthogonal validation) can help reduce the possibility of spurious results (false negative or positive results). In this manner, ...

Orthogonal techniques Analytical approaches that monitor the same CQA (s) in a biotherapeutic formulation but use different measurement principles.

Examples of orthogonal validation “One publication that stands out and really demonstrates the power of orthogonal validation is a 2016 paper from the Broad institute,” says Mills.

We propose a method for constructing orthogonal or nearly orthogonal Latin hypercubes. The method yields a large Latin hypercube by coupling an orthogonal array of index unity with a small Latin ...

We propose two methods for constructing a new type of design, called a nested orthogonal array-based Latin hypercube design, intended for multi-fidelity computer experiments. Such designs are two ...