The nucleocapsid (N) protein of severe acute respiratory syndrome-coronavirus (SARS-CoV) is a major virion structural protein. In this study, two epitopes (N1 and N2) of the N protein of SARS-CoV ...

编辑推荐： 为解决SARS-CoV-2变异株逃逸现有疫苗保护的问题，研究人员通过免疫信息学 (immunoinformatics)和反向疫苗学 (reverse vaccinology)技术，设计了一种靶向刺突蛋白 (spike)和核衣壳蛋白 (nucleocapsid)的多表位mRNA疫苗。该疫苗覆盖99.99%全球人群，能诱导强烈的B细胞 (BCR)和T细胞 ...

Their findings reveal that nucleocapsid-based vaccines are effective in preventing SARS-CoV-2 infection in distal organs, such as the brain. The study is currently available on the bioRxiv ...

Phosphorylation of the Nucleocapsid Protein The first step in determining which host kinases to use for drug development is determining the phosphorylation sites of the intended target. To do so ...

Nucleocapsid antigen samples were higher in people with COVID-19 illness who died or needed intubation within 30 days of sampling compared to those who survived or did not need intubation.

“The nucleocapsid is the most abundant protein in the virus and it’s highly immunogenic — able to produce an immune response. Thus, our new findings may facilitate the development of new antiviral ...

The nucleocapsid protein is a structural protein with an integral role in viral assembly and the packaging of genetic material (Figure 1). It is 90% conserved between SARS-CoV-1 and SARS-CoV-2 ...

Viral nucleocapsid protein is a potential antiviral drug target, serving multiple critical functions during the viral life cycle. However, the structural information of SARS-CoV-2 nucleocapsid ...

Intracellular Ebola virus nucleocapsid assembly revealed by in situ cryo-electron tomography. Cell, 2024; DOI: 10.1016/j.cell.2024.08.044 ...

Preclinical results show this next generation Adeno (hAd5) vaccine, which targets both spike (S) and nucleocapsid (N) SARS-CoV-2 proteins, generates CD4+ and CD8+ T-cell responses, both of which ...

The nucleocapsid’s cylindrical shape is made up of three layers; each layer plays a different role as the virus replicates in host cells. Before LJI’s imaging studies, the existence of the ...