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NADPH氧化酶是一类跨膜氧化还原酶,将电子从膜一侧的NADPH跨膜传递给另一侧的氧分子,生成以超氧阴离子和过氧化氢为主的活性氧类物质(ROS ...
研究人员针对NADPH氧化酶(NOXs)亚型选择性抑制难题,以非选择性抑制剂VAS2870为起点,通过苯并恶唑硫醇基团的功能化修饰,首次开发出NOX5亚型选择性共价抑制剂。该研究揭示了SNAr(亲核芳香取代)共价修饰释放活性基团的独特机制,为开发靶向NOXs亚型的选择性抑制剂提供了新策略,相关成果 ...
NADPH(还原型辅酶Ⅱ)是细胞内关键的抗氧化分子,它参与生物体内还原性生物合成以及氧化还原反应,在代谢通路中发挥重要作用。但细胞如何 ...
拟南芥叶片内源性一氧化氮波动调控过氧化物酶体活性及ROS、NADPH和H2S代谢的分子机制研究 《Plant Science》:Endogenous NO fluctuations in Arabidopsis leaves influence peroxisomal activities and ROS, NADPH, and H 2S metabolism 【字体: 大 中 小 】 ...
A metabolomics quantification of NADPH production and consumption fluxes in proliferating mammalian cells reveals that, in addition to canonical pathways such as the oxidative pentose phosphate ...
他们将类囊体跨物种递送到动物体衰老病变的细胞内,之后产生ATP(三磷酸腺苷)和NADPH(还原型辅酶II),为细胞供能,在退行性骨关节炎疾病治疗 ...
Peter Van Gestelen, Han Asard, Roland J. Caubergs, Solubilization and Separation of a Plant Plasma Membrane NADPH-O₂⁻ Synthase from Other NAD (P)H Oxidoreductases, Plant Physiology, Vol. 115, No. 2 ...
Reactive oxygen species (ROS) produced by the NADPH oxidase, respiratory burst oxidase homolog (RBOH), trigger signal transduction in diverse biological processes in plants. However, the functions of ...
NAD+, NADH as well as NADP+, NADPH have been known to play vital roles in energy metabolism, antioxidation, and reductive biosynthesis. Changes in these systems can be monitored using absorbance ...
The active NADPH oxidase complex is a six-protein complex. It has two components in its basic state: a membrane-bound complex embedded in the walls of secondary granules and separate cytosolic ...
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