本研究针对NADP+ 依赖性胞质异柠檬酸脱氢酶 (IDH1)的调控机制展开探索，通过解析小鼠IDH1与异柠檬酸及草酸乙酸的复合物晶体结构，首次发现草酸乙酸在结合活性位点的同时，还能通过变构位点（由clasp结构域形成）抑制IDH1活性，且该抑制不可被底物异柠檬酸逆转。研究揭示了IDH1的变构调控新机制 ...

在哺乳动物细胞中，有三种苹果酸酶的异构体：一种细胞膜NADP+依赖性的异构体 (ME1)，一种线粒体NAD (P)+依赖性的异构体 (ME2)和一种线粒体NADP+依赖性 ...

A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes Journal: Nature Communications Published: 2024-12-19 DOI: 10.1038/s41467-024-55302-x ...

Tethering ferredoxin-NADP+ reductase to photosystem I promotes photosynthetic cyclic electron transfer Journal: The Plant Cell Published: 2025-03-05 DOI: 10.1093/plcell/koaf042 Affiliations: 6 ...

The two isocitrate dehydrogenase activities, but not the two malate dehydrogenase activities, could be separated by ammonium sulfate precipitation. Thus, the NADP+-isocitrate dehydrogenase activity is ...

Two different isoforms of glucose-6-phosphate dehydrogenase (Glc6PDH; EC 1.1.1.49) have been partially purified from barley (Hordeum vulgare L., cv. Alfeo) roots. The procedure included an ammonium ...