The body's endogenous opioid system has three classes of opioid receptors: mu, delta, and kappa. Previous research showed that mice lacking the mu opioid receptor do not drink alcohol. A new study ...

Fentanyl, a mu-opioid receptor agonist, is one of the most commonly used analgesics in hospitals, and may induce long-lasting behavioral and somatosensory impairment in rodents. However, whether the ...

来自美国的研究团队针对胰腺癌患者广泛使用阿片类药物镇痛却与不良预后相关的现象，开展了阿片类药物对肿瘤微环境影响的研究。研究发现吗啡通过激活癌相关成纤维细胞（CAFs）中的MOR受体，显著促进胶原蛋白（如1a型和3a型）表达与ECM重构，诱导肿瘤基底 ...

Opioids are some of the oldest known treatments for pain relief, but they can cause serious side effects. A team of researchers including Susruta Majumdar, a medicinal chemist and pharmacologist at ...

PN6047 is a first-in-class small molecule that selectively activates the delta opioid receptor (DOR), avoiding interaction with the mu opioid receptor that is the basis of the addiction and other ...

Having a pill that alleviates chronic pain without adverse side effects or the risk of addiction remains an unmet pharmaceutical need for millions of people currently using traditional opioid drugs.

Researchers have observed that the length of daylight hours impacts opioid receptor levels in brown fat. When daylight hours shorten, the receptor activity levels elevate. A similar phenomenon also ...

Researchers from the Turku PET Centre, Finland, have observed that the length of daylight hours impacts opioid receptor levels in brown fat. When daylight hours shorten, the receptor activity levels ...

Brandy Schillace’s review of “Candace Pert” by Pamela Rykman (Bookshelf, Nov. 15) contains a questionable conclusion: the discovery of the mu opioid receptor in 1972 “helped launch the opioid crisis” ...

Opioids are powerful painkillers but their use is hindered because patients become tolerant to them, requiring higher and higher doses, and overdoses can cause respiratory depression and death. A ...