2023年2月2日，该研究工作以Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P？ Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance为题发表于 Journal of Medicinal ...

Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic ...

Macrocyclic compounds are cyclic molecules with a structure of 12 or more atoms. In the past decades, macrocycles have received increasing attention in drug development.

Macrocyclic drugs are an emerging class of therapeutics that promise to open up drug target spaces which are poorly addressed by small chemical entities and larger biologics. Cyclosporin is the ...

Hepatocyte growth factor (HGF) is involved in cancer progression through MET receptor signaling. Here, HiP-8, a 12 amino-acid macrocyclic peptide, was identified to selectively recognize active ...

Macrocyclic compounds are cyclic molecules with a structure of 12 or more atoms. In the past decades, macrocycles have received increasing attention in drug development.

The macrocyclic, extra-cellular – or general-purpose – manganese-based contrast agent has comparable relaxivity - the ability of a contrast agent to enhance signal intensity during an MRI scan ...

Featured events Early Career Researcher Macrocyclic and Supramolecular Chemistry (ECR MASC) Meeting 2025 2 July 2025 09:30-18:00, Oxford, United Kingdom ECR MASC 2025 is an excellent opportunity for ...

Silicon-Containing Macrocyclic Peroxides Chemists serendipitously discover that the linear silyl peroxides they set out to make form large rings instead by Stephen K. Ritter ...

Unnatural Products Inc. notched another collaboration by signing on with Argenx SE in a multitarget research collaboration. Unnatural Products, which is getting up-front, near-term payments and ...