Preclinical data demonstrates proof-of-concept for EDIT-401 with ≥90% mean LDL-C reduction in non-human primates and mouse ...

Editas Medicine (EDIT) reported in vivo preclinical proof-of-concept data for EDIT-401, an experimental, one-time therapy to significantly reduce ...

Alumni Endowed Professor of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine RNA viruses use a ...

In 1985, the Nobel Prize in Physiology or Medicine was awarded to Michael Brown and Joseph Goldstein for identifying the receptor that clears LDL particles from the bloodstream. High blood levels of ...

Editas Medicine ( ($EDIT) ) has provided an update. On October 9, 2025, Editas Medicine presented in vivo preclinical proof-of-concept data for ...

Proprotein convertase subtilisin/kexin type-9 (PCSK9) is highly expressed in adult hepatocytes. PCSK9 binds to and promotes the degradation of the low-density lipoprotein (LDL) receptor, thereby ...

We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. Back to Healio A novel agent demonstrated a ...

Heart disease caused by damage to blood vessels is the leading cause of death worldwide. Arteries become clogged with fats and cholesterol when certain proteins in the body, known as lipoproteins, ...

Foods that raise cholesterol aren’t always as straightforward as they seem. Unfiltered coffee, ghee, tropical oils, refined carbohydrates and even high-sodium foods are sneaky culprits that can ...

High levels of low-density lipoprotein (LDL) cholesterol can cause artery blockages and diseases like heart attacks and strokes. Further, it raises the risk of cardiovascular disease (CVD). Thickened ...

Patients with severe hypercholesterolemia who are unresponsive to a number of lipid-lowering therapies, including a PCSK9 inhibitor and high-dose statin, can have a significant reduction in ...