编辑推荐： 本研究针对代谢紊乱相关疾病中脂质相关巨噬细胞（LAMs）的异质性问题，通过整合多组织单细胞RNA测序数据，系统鉴定了Trem2+/Lpl+ LAMs在人和小鼠中的保守性特征及组织特异性基因程序。研究发现LAMs通过PPAR信号通路和溶酶体活性维持脂质稳态，并在动脉粥样硬化、肥胖和脂肪肝等疾病中 ...

为解决肥胖背景下棕色脂肪组织（BAT）功能失调的免疫调控机制问题，意大利罗马第二大学团队开发单细胞分析工具MACanalyzeR，发现高表达PPARγ和GDF15的脂质相关巨噬细胞（LAMs）通过激活PPAR信号通路维持BAT产热特性，为代谢疾病治疗提供新靶点。该研究发表于《Nature Communications》。

Motorola is trying to do with AI LAMs what Rabbit set out to attempt – develop an AI model that could transform your commands into action successfully. Motorola’s new experiment sticks an AI ...

How Holton interacted with the Lams changed as well. He said part of that happened when he took “creative pauses” that would last a year or more. He continued to see the Lams but felt the ...