????心肌梗死和外周动脉疾病的核心病理特征是动脉闭塞而引起的组织缺血，进而可导致患者残疾或死亡。但目前尚缺乏能够有效促进血管新生的小分子化合物。近日，中国科学院遗传与发育生物学研究所王秀杰研究员团队与复旦大学孟丹教授团队合作，鉴定出一种通过靶向抑制转录因子BACH1 (BTB and CNC homolog 1) ...

Article Published: April 1999 Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization Tomono Takahashi, Christoph Kalka, Haruchika ...

Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced ...

Eukaryotic translation initiation factor 2-α kinase 3 (PERK) plays a role in homeostasis maintenance of the mitochondria-associated membrane (MAM), which in turn has an impact on the mitochondrial ...

Critical limb ischemia (CLI) is a severe complication of peripheral artery disease (PAD). PAD occurs when plaque builds up in blood vessels that deliver blood from the heart to other areas.

Ischemia and reperfusion are relevant to many disease states ranging from the impact of diabetes on the retina to stroke, cardiovascular disease and kidney dysfunction. 1,2 However, the current ...

Oxidative stress is part of the oxygen paradox, 21 in which the reoxygenation of ischemic myocardium generates a degree of myocardial injury that greatly exceeds the injury induced by ischemia ...

Scientists at the University of Virginia School of Medicine and the University of Michigan have developed a monoclonal ...

Acute mesenteric ischemia is caused by arterial insufficiency or venous obstruction About half of all cases of acute mesenteric ischemia are caused by arterial embolism originating from a cardiac ...

Cutaneous ischemia‐reperfusion injury is exacerbated by IL‐36 receptor antagonist deficiency. Journal of the European Academy of Dermatology and Venereology, 2021; DOI: 10.1111/jdv.17767 ...

Skin wounds from ischemia-reperfusion injuries—tissue damage caused by blood returning to tissues after a period of oxygen deprivation—may not heal appropriately in some patients, owing to ...