Marti-Solano et al. 3 analysed 625 GPCR isoforms expressed across 30 human tissues, and show that there is often more than one isoform of the same receptor in a tissue. a, The authors catalogued ...

Researchers created a pH-gradient cation exchange separation to purify IgG2 disulfide isoforms in their native state. The pH-gradient cation exchange method can be used as a potential alternative for ...

The p53 protein is a major mediator of the cellular response to genotoxic stress and is a crucial suppressor of tumor formation. In a variety of organisms, p53 and its paralogs, p63 and p73, each ...

Our study identifies thousands of novel brain expressed isoforms, and confirm the importance of alternative splicing in the cortex, dramatically increasing transcriptional diversity and ...

Isoforms can be produced through normal cellular processes and regulation, whereas variants often represent genetic changes or mutations that can be associated with diseases or genetic diversity ...

These isoforms have been suggested as the reason for the occasionally observed opposing roles of STAT3 in cancer: an oncogene, on one hand, and a tumor suppressor on the other.

Although the combination treatment enhanced pain relief when administered to the spinal cord, Streicher and his colleagues previously found that inhibition of Hsp90 in the brain blocked these effects, ...

These isoforms have been suggested as the reason for the occasionally observed opposing roles of STAT3 in cancer: an oncogene, on one hand, and a tumor suppressor on the other. In this new study ...

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease. Nat Commun. 2025;16 (1):4883. doi: 10.1038 ...

Isoforms have a wide range of functions, and we've long known that alternative splicing plays an important role in regulating gene function in the brain, being implicated in many brain diseases.

In neurons, Tau (MAPT - microtubule-associated protein tau) is a protein that binds to microtubules (the neuron’s transport system), which stabilizes their formation and maintenance. Tau is ...

Simonetta Santi, Geraldine Locci, Rossella Monte, Roberto Pinton, Zeno Varanini, Induction of nitrate uptake in maize roots: expression of a putative high-affinity nitrate transporter and plasma ...