新预测的蛋白isoforms构成了数据库的重要部分。 其中75%基因至少有一个pNIC或pNNC；三分之一的基因对应的丰度最高的蛋白isoform与GENECODE 中的参考isoform不对应；且42.5% (1215)的蛋白isoforms是之前未发现过的，这进一步说明了构建样品特异性的蛋白数据库的重要性。

Isoforms can be produced through normal cellular processes and regulation, whereas variants often represent genetic changes or mutations that can be associated with diseases or genetic diversity ...

These isoforms have been suggested as the reason for the occasionally observed opposing roles of STAT3 in cancer: an oncogene, on one hand, and a tumor suppressor on the other.

The method developed by Tripathi and colleagues detects isoforms as small as 0.1 ng/µL for supercoiled and linear isoforms, and 0.5 ng/µL for the circular isoform.

Alternative splicing results in six tau isoforms, which are classified according to whether they contain three (3R) or four (4R) microtubule-binding domains. While all six isoforms are found in the ...

Two distinct isoforms of cinnamyl alcohol dehydrogenase, CAD 1 and CAD 2, have been purified to homogeneity from xylem-enriched fractions of Eucalyptus gunii Hook and partially characterized. They ...

Although the combination treatment enhanced pain relief when administered to the spinal cord, Streicher and his colleagues previously found that inhibition of Hsp90 in the brain blocked these effects, ...

New publication: Role of PKC isoforms in cardiomyocyte hypertrophy Our article entitled “Pharmacological protein kinase C modulators reveal a pro-hypertrophic role for novel protein kinase C isoforms ...

To see where the two isoforms localize in cells, Xiao turned to immunohistochemistry. In spinal motor neurons from controls and ALS cases, the long C9ORF72 typically appeared in the cytoplasm, ...

In neurons, Tau (MAPT - microtubule-associated protein tau) is a protein that binds to microtubules (the neuron’s transport system), which stabilizes their formation and maintenance. Tau is ...