这篇综述系统阐述了ADAM28（解整合素金属蛋白酶28）在恶性肿瘤中的多重作用机制，重点探讨其通过切割IGFBP-3、vWF和CTGF等底物，调控肿瘤增殖、转移、耐药及免疫逃逸的分子通路（如PI3K/AKT/mTOR、RAS/MAPK），并论证其作为新型生物标志物和靶向治疗靶点的潜力。

RESULTS: Plasma IGFBP-3 levels were lowest in patients with bone metastases (P ≤ .043). IGFBP-2 levels were elevated in prostate cancer patients compared with healthy subjects (P ≤ .006). However, ...

While lower baseline IGF-I/IGFBP-3 levels were predictive of BT efficacy at 5 and 10 y, higher levels at 10 y were associated with a lower benefit of BT. E2/SHBG had a tendency to be prognostic and ...

Insulin-like growth factor binding protein-3 (IGFBP-3) seems to take a lead role in healthy eyesight, according to researchers at the University of Florida (UF), Harvard Medical School, and the ...

R Kaaks, A Lukanova, S Rinaldi, C Biessy, S Söderberg, T Olsson, U-H Stenman, E Riboli, G Hallmans, P Stattin, Interrelationships between plasma testosterone, SHBG, IGF-I, insulin and leptin in ...

Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-32214-2 ...

Shingo Kajimura, Katsumi Aida, Cunming Duan, Donald F. Steiner, Insulin-Like Growth Factor-Binding Protein-1 (IGFBP-1) Mediates Hypoxia-Induced Embryonic Growth and Developmental Retardation, ...