In nature, halogenation is a strategy used to increase the biological activity of secondary metabolites, compounds that are often effective as drugs. However, halides are not particularly reactive ...

Likewise, halogenation has remained a popular tool for tweaking a drug candidate's biological properties for nearly a century, notes medicinal chemist Paul S. Anderson, now retired after a 40-year ...

The nine-residue lipodepsipeptide syringomycin E, elaborated as a phytotoxin by Pseudomonas syringae pv. syringae B301D contains a 4-Cl-L-Thr-9 moiety where failure to chlorinate results in a 3-fold ...