以 TP53 ...

Cas9 in germline editing presents opportunities for genetic disease correction, alongside risks of off-target effects and ...

This germline testing is important not just for the patient, but has wider implications for their families as well, as you mentioned. So then, beyond those recommendations for germline testing, which ...

Multigene germline genetic testing should be considered for all patients with advanced cancer to better guide treatment selection, according to study results published in Journal of Clinical ...

The study revealed unexpected and sex-specific effects of germline regulation on longevity and somatic repair in vertebrates. Contrary to classical evolutionary theories, it turns out that ...

Most of the mechanisms involved in the generation of mutations were related to defects in the repair of damaged DNA. For example, the researchers associated rare inherited variants in genes such ...

About 15% of a large cohort of patients with lung cancer had pathogenic germline variants, nearly all of which could be clinically actionable, according to study results presented during an ASCO ...

Germline invasions have been repeatedly experienced during vertebrate evolution and have shaped vertebrate genomes, including the lineage leading to modern humans.

Some biologists are starting to consider this tranquil pool of cells a “functional germline,” in a twist on a mid-20th-century French theory called the méristème d’attente, or “waiting meristem,” ...

Germline predisposition to myeloid cancers is rare: Initial descriptions of hereditary hematopoietic malignancies (HHMs) asserted that they are rare, giving clinicians the impression that they would ...