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基于Steered Molecular Dynamics揭示GerAB残基Y97、L199和F342通过调控水通道 ...
本研究通过Steered Molecular Dynamics(SMD)模拟结合定点突变实验,鉴定出GerAB蛋白中三个关键残基(Y97、L199、F342)对水通道功能的调控作用,并揭示其在维持Germinant Receptor(GR)结构稳定性及Germinosome功能协同中的核心机制,为理解芽孢萌发过程提供重要分子基础。
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