撰文丨王聪编辑丨王多鱼排版丨水成文结直肠癌（CRC）是第三常见的恶性肿瘤，也是癌症相关死亡的第二大原因。靶向 PD-1/PD-L1、CTLA-4 ...

病毒感染的“帮凶” SARS-CoV-2感染中，GRP78与病毒刺突蛋白（SARS-2-S）及ACE2形成复合物，促进病毒进入。 抗GRP78抗体MAb159可阻断感染，而BOLD-100和HA15等抑制剂通过抑制GRP78表达或活性，显著降低病毒载量，甚至对埃博拉病毒有效。 治疗前景与挑战 ...

在一项新的研究中，来自美国圣犹大儿童研究医院的研究人员开发出首个靶向 GRP78 的嵌合抗原受体（CAR）T细胞（CAR-T，下称 GRP78 CAR-T）。

通常情况下，GRP78驻留在细胞的内质网中。 但当细胞处于压力下时，伴侣蛋白会迁移到细胞核，在那里它会改变基因活性并改变细胞的行为，使癌 ...

We show here that anti-GRP78 autoantibodies upregulate TF and its PCA through a mechanism involving depletion of ER Ca2+ stores. This very effect on ER Ca2+ stores also caused activation of the ...

These and other GRP78 inhibitors are now being tested as treatments for both COVID-19 and cancer. These drugs may also prove useful for treating future coronaviruses that depend on GRP78 for entry ...

ER protein GRP78 has a critical role in protecting renal cell carcinoma cells from hypoxic and hypoglycemic stress induced by antiangiogenic therapy. Knockdown of GRP78 sensitizes RCC cells to ...

Endoplasmic reticulum (ER) stress and its main regulator GRP78 (glucose-regulated protein 78 kDa) appear to be involved in the pathogenesis of pulmonary diseases, and GRP78 was found to be a biomarker ...

The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI42164 ...

GRP78 expression was detected in both SARS-CoV-2-infected and un-infected pneumocytes as determined by multiplexed immunostaining for nucleocapsid protein. In macrophages, immunohistochemical staining ...

GRP78 is part of a family of proteins called chaperones. The job of a chaperone is to help shape chains of amino acids into proteins and then to keep those proteins active in the correct 3D shape. The ...