针对未成熟恒牙不可逆性牙髓炎导致的根尖孔未闭合问题，四川大学华西口腔医院团队开发了G-CSF/锂皂石 (laponite)/胶原复合支架系统。研究发现50 ng/ml G-CSF能特异性促进根尖乳头干细胞 (SCAPs)增殖、迁移和成牙本质分化 (DSPP , DMP-1 )，锂皂石实现G-CSF缓释，体内实验证实该复合物可高效诱导SCAPs归巢形成 ...

IL-17A通过G-CSF间接驱动Siglec-F+中性粒细胞分化 研究发现IL-17A并不直接诱导分化，而是刺激肺上皮（EpCAM +）和血管内皮（CD31 +）细胞分泌G-CSF。 中和G-CSF可阻断BALF诱导的Siglec-F + 细胞分化，而GM-CSF中和无此效果。

G-CSF 通过与 HSA 的融合，增加分子量的同时可明显抑制 G-CSF 受体介导的清除途径，能显著延长药物体内半衰期，在临床使用中可以降低给药频率 ...

G-CSF has a suspected immunosuppressive effect on peripheral blood stem cell allografts, including the shifting of cytokine production towards a type-2 helper cell response. 13, 14 In addition, G ...

6月27日，迈威生物连续发布两则公告，旗下两款产品完成BD交易，总交易金额折合人民币合计达到47亿元，首付款合计约6.6亿元。 其中，与齐鲁制药就新一代长效 G-CSF（高活性改构细胞因子）注射用阿格司亭α（迈粒生，8MW0511）签署许可协议，后者获得在大中华区内开发、生产、改进、利用和商业化许可产品的权利。该笔交易首付款和销售里程碑合计最高达 5 亿元，包括 3.8 亿元首付款。 注射用阿格司 ...

G-CSF does not work instantly, but it can decrease the duration of neutropenia when used prophylactically and may be useful in the setting of certain severe infections.

Recently, concerns about the use of G-CSF during the COVID-19 pandemic have also been acknowledged by ASCO and the European Society for Medical Oncology; it was emphasized that G-CSF should be used ...

There were 3,426 chemotherapy regimens corresponding to 2,968 patients. There were a total of 387 (11.3%) G-CSF–treated patients and 3,095 G-CSF administrations during the study period. G-CSF use was ...

All patients had a risk for FN of at least 20%. One group of patients was randomly assigned to the G-CSF pegfilgrastim during all 6 cycles of chemotherapy, which is the standard of care.

The efficacy of G-CSF affects clinician choice only in secondary prophylaxis for febrile neutropenia in patients receiving chemotherapy, suggests a French survey.