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3月
SWI/SNF PBAF 复合物:解锁染色质抑制区域的关键 “钥匙 ...
SWI/SNF(switch/sucrose non-fermentable)染色质重塑因子具有独特功能,难以剖析。不同癌症在特定亚基上存在突变,比如黑色素瘤中多溴相关 BAF(PBAF)的特定成分 ARID2 发生突变。在此,研究人员对黑色素细胞和黑色素瘤中的 SWI/SNF 复合物及其相关染色质状态进行了表观基因组分析。时间分辨方法显示 ...
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