吉林大学分子酶学工程教育部重点实验室的王磊教授课题组致力于研究利用人工酶挖掘新型非天然反应，以实现绿色高效的有机合成。通过设计全新的人工金属酶，以《Enzyme-Controlled Bidirectional Enantioselectivity in Asymmetric Decarboxylative Mannich Reaction for Synthesizing ...

编辑推荐： 研究成果以“基于过渡态知识的机器学习实现钯电催化氧化碳氢键活化反应的对映选择性预测（Enantioselectivity prediction of pallada-electrocatalyzed C–H activation using transition state knowledge in machine learning）”为题，于2023年1月30日在线发表于《自然?合成 ...

AS SINGLE-ENANTIOMER drugs dominate the pharmaceutical market (1), custom manufacturers and technology providers are developing novel routes using biocatalysis and chemocatalysis, alone and combined, ...

The group used bifunctional thiourea catalysts to promote an asymmetric oxo-conjugate addition to β-ketoester alkylidene in high yields with enantioselectivity of 80–94% ee for aryl and alkyl ...

They used the catalyst to perform a carbon-carbon bond-forming reaction, the Michael addition of malonate esters to nitroalkenes, with up to 98% enantioselectivity (ACS Cent. Sci. 2015, DOI: 10. ...