Using electronic health record data from 92,616 ICU admissions at 13 Dutch hospitals, investigators found that 13,492 involved AKI (15%) based on serum creatinine criteria alone. After adjustment for ...

PHOENIX -- Tailoring potential drug-drug interaction (DDI) alerts to the intensive care unit (ICU) setting significantly reduced the number of administered high-risk drug combinations, a cluster ...

Drug therapy is a complex process with numerous parameters modulating its success and safety. The selection of a drug and the definition of its dosage regimen, which must consider both disease and ...

After approval of the study protocol by the ethics committee of the Medical Faculty of the University of Heidelberg, we evaluated parenteral drug treatment in patients admitted to a 12-bed ICU in a ...

To get life-threatening diseases under control, patients in the intensive care unit usually are administered many medications at the same time. Even for experts, it is difficult to keep track of the ...

Critical care medicine presents unique challenges for pharmacotherapy due to profound pathophysiological alterations that affect drug absorption, distribution, metabolism and excretion.