There can be many reasons why the Mouse double-click does not open files & folders in Windows. Here are some fixes to resolve this issue.

Go to "Control Panel>Folder Options" and make sure the "Double-click to open an item" is selected. If it already is, maybe you do have a mouse problem.

If I double-click any MS Office file (Excel, Word, etc) to open it, it literally takes nearly 5 minutes to load.Anyone else had this happen? Anyone know how to fix it? It is EXTREMELY frustrating.

Of course, this feature is not foreign anymore to some users. In fact, some Microsoft Edge users already discussed the potential of double-clicking in closing active tabs in a 2020 support forum.