Data shows that EP262 attenuates mast cell degranulation in multiple species including human MRGPRX2 knock-in mice, Beagle dogs and human ex vivo skin explants Results support the initiation of ...

Mast cell degranulation may be associated with very severe symptoms, such as deep skin swelling, typically in the face, lips, or throat.

Degranulation of MCs in SARS-CoV-2 infected mice. (A) C57BL/6 mice were inoculated intranasally with hACE2-AAV to induce hACE2 expression in the airways.

At the ongoing AAAAI meeting in San Antonio, researchers from Escient Pharmaceuticals Inc. presented preclinical data for the Mas-related G-protein coupled receptor X2 (MRGPRX2) antagonist EP-262, ...

Polarized degranulation was dependent on FcεRI crosslink as it was not observed at the hMC/B-cell contact site in the absence of anti-CD20 IgE sensitization (Fig. 2c).

这篇综述系统阐述了STOM基因编码的Stomatin及其同源蛋白（SLPs）通过SPFH结构域调控转运蛋白活性的分子机制，重点揭示了其在肿瘤转移（Cancer Metastasis）、中性粒细胞脱颗粒（Neutrophil Degranulation）中的双向调节作用，并指出未来研究应聚焦于其寡聚化（Homo-oligomerization）和翻译后修饰（Post-modification ...

Ameeta S. Kalokhe, Toidi Adekambi, Chris C. Ibegbu, Susan M. Ray, Cheryl L. Day, Jyothi Rengarajan, Impaired Degranulation and Proliferative Capacity of Mycobacterium tuberculosis-Specific CD8⁺ T ...

The aberrant degranulation associated with vibratory urticaria suggests that dermal mast cells may respond to physical forces through ADGRE2, in addition to their known response to allergenic ...

Degranulation of peritoneal mast cells was assayed by using alcian blue staining in guinea pigs, and the degranulation index (DI) was calculated. CA-induced degranulation of RBL-2H3 cells was also ...

The infant had also been treated with inhibitors of mast-cell degranulation (cromolyn), of histamine H 1 and H 2 receptors (hydroxyzine and ranitidine, respectively), and of the cysteinyl ...