Data shows that EP262 attenuates mast cell degranulation in multiple species including human MRGPRX2 knock-in mice, Beagle dogs and human ex vivo skin explants Results support the initiation of ...

The aberrant degranulation associated with vibratory urticaria suggests that dermal mast cells may respond to physical forces through ADGRE2, in addition to their known response to allergenic ...

The infant had also been treated with inhibitors of mast-cell degranulation (cromolyn), of histamine H 1 and H 2 receptors (hydroxyzine and ranitidine, respectively), and of the cysteinyl ...

At the ongoing AAAAI meeting in San Antonio, researchers from Escient Pharmaceuticals Inc. presented preclinical data for the Mas-related G-protein coupled receptor X2 (MRGPRX2) antagonist EP-262, ...

Degranulation of MCs in SARS-CoV-2 infected mice. (A) C57BL/6 mice were inoculated intranasally with hACE2-AAV to induce hACE2 expression in the airways.

Mast cell degranulation may be associated with very severe symptoms, such as deep skin swelling, typically in the face, lips, or throat.