Cell surface receptors represent a vast majority of drug targets. Efforts have been conducted to develop biosensors reporting their conformational changes in live cells for pharmacological and ...

Dopamine (DA) controls a wide variety of physiological functions in the central nervous system as well as in the neuroendocrine and gastrointestinal systems. DA signaling is mediated by five cloned ...

An oral compound, SEP-363856, that does not act on dopamine D2 receptors but has agonist activity at trace amine–associated receptor 1 (TAAR1) and 5-hydroxytryptamine type 1A (5-HT 1A) receptors, may ...

Shanghai Institutes for Biological Sciences and Shanghaitech University have identified dopamine D2 receptor and/or 5-HT receptor agonists reported to be useful for the treatment of depression and ...

A French surgeon, Henri Laborit, discovered the first antipsychotic drug, chlorpromazine (Thorazine), in 1952 while experimenting with compounds to enhance anesthesia. Since then, antipsychotic drugs ...

Shanghai Pharmaceuticals Holding Co. Ltd. has disclosed aza-ergoline derivatives acting as dopamine D2 receptor and/or D3 receptor agonists reported to be useful for the treatment of attention deficit ...

A digital signal processing technique long used by statisticians to analyze data is helping scientists understand the roots of memory and learning, Alzheimer's and Parkinson's diseases and stroke. A ...