US FDA grants orphan drug designation to Sanofi’s SAR446523, a GPRC5D monoclonal antibody, earns to treat multiple myeloma: Paris Friday, August 1, 2025, 09:00 Hrs [IST] The US ...

Immune checkpoint inhibitors have revolutionized cancer treatment, but not all patients respond equally. Now, researchers ...

Neutrophils, once considered simple foot soldiers of innate immunity, are now recognized as complex players in cancer.

Sanofi’s SAR446523, a GPRC5D monoclonal antibody, earns orphan drug designation in the US for multiple myeloma Designation granted for IgG1-based GPRC5D monoclonal antibody for the potential treatment ...

A549 cells (2.5K/well) were seeded with PBMCs that were activated with IL-2 (10 ng/ml) and anti-CD3 (10 ng/ml). Quantification of cytotoxicity was performed based on the red fluorescent intensity.

This effect of pyruvate was concentration dependent. These paradoxical effects of pyruvate on cysteine, i.e. the reduction of its cytotoxicity and the stabilization as an SH compound, are probably due ...

Blockade of CRM1 with SINE induces cytotoxicity in neoplastic cells, but only reversible cell cycle arrest in normal cells. We report on the potential of SINE for the treatment of molecular subtypes ...

Paris: Sanofi has received orphan drug designation from the US Food and Drug Administration (FDA) for SAR446523, an ...

IncuCyte ® cytotoxicity assay Real-time, automated cytotoxicity assays can be achieved within a tissue culture incubator using the IncuCyte ® s3 live-cell imaging and analysis system.

Background: CD74 (DR-associated invariant chain) is expressed alone or with DR in a wide range of hematologic cancers and solid tumors. Humanized anti-CD74 mAb, milatuzumab (Immunomedics, Morris ...