Conformational changes in proteins, which occur at the nanoscale, are fundamental to processes ranging from enzyme catalysis and chemical signaling to cell division and differentiation.

Alan Cooper, Conformational fluctuation and change in biological macromolecules, Science Progress (1933-), Vol. 66, No. 264 (Winter 1980), pp. 473-497 ...

How proteins in our cells attain their correct three-dimensional structure is crucial to their function—and to our health.

Synopsis Conformational Design has played a key role in the medicinal chemistry of small molecule clinical candidates over the last 20 years. A key learning from multiple projects supported by ...

spectra of proteins, as compared to PDB reported values. α-helical and β-sheet content, predicted via the multivariate model as a function of temperature for the same set of BSA data shown in Figure 1 ...

How proteins in our cells attain their correct three-dimensional structure is crucial to their function—and to our health.