临床中，CYP2D6基因型具有多态性（包括等位基因*2、*2A、*3、*4、*6、*7、*8、*9、*10、*14、*17、*29、*35、*41A），美国FDA建议ER阳性乳腺癌患者在接受TAM ...

为解决药物基因组学（PGx）检测中 CYP2D6 基因表型转换影响检测结果准确性的问题，研究人员对比不同基因型预测代谢表型组的 CYP2D6 表达。 结果发现组内表达差异大，ALB 等是重要预测指标。 该研究对指导临床用药意义重大。

来自All of Us研究项目的研究人员通过分析31,669例接受CYP2D6代谢型阿片类药物（氢可酮、曲马多、可待因、羟考酮）治疗的患者数据，发现CYP2D6中间代谢型 (pIM)和弱代谢型 (pPM)患者因疼痛就诊急诊科的风险显著高于正常代谢型 (pNM)和超快代谢型 (pUM)（加权OR=1.19）。研究提示整合CYP2D6基因型和药物相互 ...

CYP2D6是CYP肝药酶的一种，在他莫昔芬转化为活性更高的代谢产物“内昔芬”过程中起重要作用，而托瑞米芬的代谢则不受CYP2D6的影响。

CYP2D6 activity score was determined for each patient according to the methods introduced by Gaedigk et al. 22 In short, a value was assigned to each allele, and the activity score was the sum of the ...

December 10, 2010 (San Antonio, Texas) — New analyses of data from 2 large trials have found no association between the CYP2D6 genotype and the effectiveness of tamoxifen in preventing breast ...

CYP2D6, which stands for Cytochrome P450 2D6, is one of the most important enzymes involved in drug metabolism. It is responsible for the breakdown of nearly a quarter of all medicines prescribed.

The phenotype of ultrarapid CYP2D6 metabolism was confirmed by calculation of the partial metabolic clearance related to O -demethylation of dextromethorphan, with a value of 0.48 indicating a ...

具体产品为人类CYP2D6基因多态性检测试剂盒（荧光PCR法），注册证编号为国械注准20243402615，有效期至2029年12月16日，用于体外定性检测人静脉全血 ...

The question of whether genetic polymorphisms of CYP2D6 can affect treatment outcome in patients with early postmenopausal breast cancer has been a matter of debate. With the recent negative results ...